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Paclitaxel is a successful chemotherapeutic, but it can produce peripheral neuropathies and other adverse effects on neuronal function (FDA package insert on TAXOL). Assessments of these neurotoxic effects are typically done using in vivo models, which provide limited evaluative throughput. CNS assay systems, such as the NeuroPrime Cell Kit, may provide a useful model for studying the off target neurotoxicity of paclitaxel (Figure 2, bottom panel) and related agents..