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This manuscript has presented a preliminary epidemiology of tryptamine and phenethylamine among high-risk youth. Such measures may allow for generalizations about tryptamine and phenethylamine use among youth to emerge. These characteristics suggest that these youth are somewhat dissimilar from the general population of young people, and findings and conclusions regarding uncommon tryptamines and phenethylamines may thus be distinct among them. Furthermore, recent research indicates positive medicinal qualities associated with the use of the tryptamines psilocybin and LSD on humans (see Griffiths et al., 2006; Sewell et al., 2006), and others have suggested the potential therapeutic utility of other tryptamines, such as DMT and Ibogaine, and phenethylamines, such as MDMA and mescaline (see McKenna, 2004; Sessa, 2005; Vastag, 2005). Exploring the further utility of tryptamines and phenethylamines may lead to novel and successful therapeutic and other interventions aimed at improving mental and physical health. The long-term negative health outcomes, such as cognitive impairment, drug dependence, and mental health disorders, associated with the use of the tryptamines and phenethylamines are unknown.

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